D'Orientine™ S - Date Pam Kernal Extract-
Phoenix dactylifera or date palm is native to the Euphrates basin and it grows in a calm, soothing and restful oasis.
The Date Palm extract contains 7 compounds that act in synergy to delay the visible effects of aging:
* Phytosterols ~ Improves barrier function
* Phytosteroids ~ Hormone-like activity
* Isoflavones ~ Anti-aging
* Ursolic acid ~ Regenerating
* Policosanols ~Supports neuro-immune system
* Tocotrienols ~ Antioxidant
* Vitamin A ~ Antioxidant
A study published in the ‘International Journal of Tissue Reactions’ showed that date palm reduced the surface area of wrinkles by 27.6% and reduced wrinkle depth of the study participants by 3.52%.
The Date Palm Extract used in our anti-ageing formula ‘Rejuvenate’ is D'Orientine™ S. You can find out more information below about clinic studies using the extract.
D'Orientine™ S Clinical Studies:
In a clinical anti-ageing study collagen 1 synthesis showed an increase of 28%. Skin showed a better preserved structure with greatly reduced signs of cellular damage and stress with reductions in oedema, chromatin condensation and apoptose.
*Collagen 1 Synthesis: Cell culture: human fibroblasts Product application: Active ingredient 1% Application time: 24 hours Evaluation: Immunoblotting
*DHEA like activity: Culture models: ex-vivo human skin Product application: Placebo cream, DHEA 1%, active ingredient at 2.5% Application time: 5 days Evaluation: H&E staining
During the anti-wrinkle clinical study, the depths of wrinkles on the volunteers were reduced by a total of 27.6% with an individual wrinkle depth reduction of 3.52%.
*D'Orientine™ S, Type: double blind clinical study Subjects: 10 healthy female volunteers, aged between 46 and 58 Product application: active ingredient at 2.5% in a cream, placebo cream Treated zone: eye zone area Application time: 5 weeks Evaluation: pictures, silicon replicas, statistical analysis
The anti-oxidant clinical study found that there was a 65% reduction in lipid peroxidation, which is a key preventative of cell damage. There was a 66% increase in manganese superoxide dismutase, which is the first line of antioxidant defence and a vast 85% increase in catalase activity, which reinforces the natural antioxidant defence system of the skin.
* Lipid Peroxidation: Cell culture: human fibroblasts Product application: Active ingredient 1% Application time: 24 hours UVA: 4 J/cm2 Evaluation: spectrophotometer
* mN SOD activity: Cell culture: human fibroblasts Product application: Active ingredient 1% Application time: 24 hours UVA dose: 4 J/cm2 Evaluation: electrophoretic MnSOD activit
*Catalase activity: Cell culture: human fibroblasts Product application: Active ingredient 1% Application time: 24 hours UVA dose: 4 J/cm2 Evaluation: spectrophotomete