D'Orientine™ S  - Date Pam Kernal Extract- 

 

Phoenix dactylifera or date palm is native to the Euphrates basin and it grows in a calm, soothing and restful oasis.

 

The Date Palm extract contains 7 compounds that act in synergy to delay the visible effects of aging:

 

* Phytosterols ~ Improves barrier function

* Phytosteroids ~ Hormone-like activity

* Isoflavones ~ Anti-aging

* Ursolic acid ~ Regenerating

* Policosanols ~Supports neuro-immune system

* Tocotrienols ~ Antioxidant

* Vitamin A ~ Antioxidant

 

A study published in the ‘International Journal of Tissue Reactions’ showed that date palm reduced the surface area of wrinkles by 27.6% and reduced wrinkle depth of the study participants by 3.52%.

 

The Date Palm Extract used in our anti-ageing formula ‘Rejuvenate’ is D'Orientine™ S. You can find out more information below about clinic studies using the extract.

 

D'Orientine™ S Clinical Studies:

In a clinical anti-ageing study collagen 1 synthesis showed an increase of 28%. Skin showed a better preserved structure with greatly reduced signs of cellular damage and stress with reductions in oedema, chromatin condensation and apoptose.

*Collagen 1 Synthesis: Cell culture: human fibroblasts Product application: Active ingredient 1% Application time: 24 hours Evaluation: Immunoblotting

*DHEA like activity: Culture models: ex-vivo human skin Product application: Placebo cream, DHEA 1%, active ingredient at 2.5% Application time: 5 days Evaluation: H&E staining

 

During the anti-wrinkle clinical study, the depths of wrinkles on the volunteers were reduced by a total of 27.6% with an individual wrinkle depth reduction of 3.52%. 

 

*D'Orientine™ S, Type: double blind clinical study Subjects: 10 healthy female volunteers, aged between 46 and 58 Product application: active ingredient at 2.5% in a cream, placebo cream Treated zone: eye zone area Application time: 5 weeks Evaluation: pictures, silicon replicas, statistical analysis

 

The anti-oxidant clinical study found that there was a 65% reduction in lipid peroxidation, which is a key preventative of cell damage. There was a 66% increase in manganese superoxide dismutase, which is the first line of antioxidant defence and a vast 85% increase in catalase activity, which reinforces the natural antioxidant defence system of the skin.

 

* Lipid Peroxidation: Cell culture: human fibroblasts Product application: Active ingredient 1% Application time: 24 hours UVA: 4 J/cm2 Evaluation: spectrophotometer

* mN SOD activity: Cell culture: human fibroblasts Product application: Active ingredient 1% Application time: 24 hours UVA dose: 4 J/cm2 Evaluation: electrophoretic MnSOD activit

*Catalase activity: Cell culture: human fibroblasts Product application: Active ingredient 1% Application time: 24 hours UVA dose: 4 J/cm2 Evaluation: spectrophotomete

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